小儿腹泻应用乳糖酶的干预研究

【目的】 通过对腹泻患儿继发性乳糖不耐受(Secondary lactose intolerance,SLI)的干预研究,为临床治疗提供科学依据。 【方法】 应用尿半乳糖测定试剂盒,对腹泻患儿的尿液进行检测,将结果为阳性的患儿随机分到乳糖酶制剂组、无乳糖奶粉组及对照组,比较三组疗效及疗程。 【结果】 SLI发病率与年龄有关,年龄越小,发病率越高,各年龄组之间差异有统计学意义(P＜0.01);与感染有关,轮状病毒感染组高于其他组,差异有统计学意义(P＜0.005);三个治疗组的总有效率有差别(P＜0.005),前两组之间无差别;三组的病程有差别(P＜0.01),前两组之间无差别。 【结论】 年龄越小,SLI发病率越高;轮状病毒感染SLI发病率高于其他病因;采用进口医用乳糖酶制剂及无乳糖奶粉治疗均可提高疗效、缩短病程,但给予乳糖酶是解决SLI的根本方法。

Study the effect of lactase on infantile diarrhea

【Objective】 To observe the incidence of secondary lactose intolerance(SLI) of diarrhea children,observing the efficacy of treatment after giving medical lactase import agents and lactose-free milk powder intervention. 【Method】 To detect the urine of diarrhea children by the urinary galactose kit,children with positive results were randomly assigned to three groups,lactose-free milk group,without lactose-free milk group and control group,to compare the curative effect and course of the three groups. 【Results】 The incidence of diarrhea secondary lactose intolerance(SLI) was related with age,the younger ones had the higher incidence;various age groups were significantly different(P<0.01);SLI was infection-related,and rotavirus infection group was higher than other groups(P<0.005);there were differences of the total effective rate to three treatment groups(P<0.005),and there was no difference between the first two groups;the course of the third group was different(P<0.01),and there was no difference between the first two groups. 【Conclusions】 The younger ones have higher incidence of SLI.The incidence of rotavirus infection is higher than other causes of morbidity;imported medical lactase and lactose-free milk powder formulations may enhance the effectiveness of treatment to shorten the course of disease,but to supply lactase is the fundamental method to solve the question of SLI.