| RKIP在肺鳞癌组织中的表达及其意义 |
| |
| 引用本文： | 徐海源,王馨,沈文香,王李强,沈刚,陈敏斌,周丽娜. RKIP在肺鳞癌组织中的表达及其意义[J]. 中国肺癌杂志, 2011, 14(3): 194-198. DOI: 10.3779/j.issn.1009-3419.2011.03.03 |
| |
| 作者姓名： | 徐海源 王馨 沈文香 王李强 沈刚 陈敏斌 周丽娜 |
| |
| 作者单位： | 1. 江苏大学附属昆山医院,昆山市第一人民医院肿瘤科,昆山,215300
2. 厦门大学附属中山医院肿瘤科,厦门,361004 |
| |
| 摘 要： | 背景与目的 Raf激酶抑制蛋白(Raf kinase inhibitor protein,RKIP)属于磷脂酰乙醇胺结合蛋白家族的成员,可干扰Raf-1-MEK1/2-ERK1/2信号通路,抑制NF-κB和G蛋白偶联受体激酶等信号传导过程,且RKIP的表达减弱或丢失与多种肿瘤的发生发展以及侵润转移相关。本研究旨在探讨RKIP在肺鳞癌组织中的表达及其与肺鳞癌临床病理的相关性。方法应用RT-PCR方法检测56例肺鳞癌组织及其癌旁正常组织中RKIP基因的表达,计算其阳性率;并用Western blot方法检测肺鳞癌组织及其癌旁正常组织中RKIP蛋白的表达变化。结果 RKIP mRNA在肺鳞癌组织中表达的阳性率明显低于癌旁正常组织(P<0.05),在有淋巴结转移者中的表达阳性率明显低于无淋巴结转移者(P<0.05),但与患者的性别、年龄、肿瘤的大小及分化程度无明显关系(P>0.05)。RKIP蛋白在肺鳞癌组织中表达明显低于癌旁正常组织(P<0.05)。结论 RKIP的低表达可能与肺鳞癌的发生及侵袭转移有关。
|
| 关 键 词： | 肺肿瘤 Raf激酶抑制蛋白 转移 |
The Expression and Significance of RKIP in Lung Squamous Cell Carcinoma Tissues |
| |
| Haiyuan XU,Xin WANG,Wenxiang SHEN,Liqiang WANG,Gang SHEN,Minbin CHEN,Lina ZHOU. The Expression and Significance of RKIP in Lung Squamous Cell Carcinoma Tissues[J]. Chinese journal of lung cancer, 2011, 14(3): 194-198. DOI: 10.3779/j.issn.1009-3419.2011.03.03 |
| |
| Authors: | Haiyuan XU Xin WANG Wenxiang SHEN Liqiang WANG Gang SHEN Minbin CHEN Lina ZHOU |
| |
| Affiliation: | Haiyuan XU1,Xin WANG2,Wenxiang SHEN1,Liqiang WANG1,Gang SHEN1,Minbin CHEN1,Lina ZHOU1 1Department of Medical Oncology,the First People's Hospital of Kunshan,Affiliated to Jiangsu University,Kunshan 215300,China,2Department of Medical Oncology,Zhongshan Hospital,Affiliated to Xiamen University,Xiamen 361004 |
| |
| Abstract: | Background and objective Raf kinase inhibitory protein(RKIP) belongs to the phosphatidylethanolamine binding protein(PEBP) family.RKIP is an endogenous inhibitor of the Raf-1-MEK1/2-ERK1/2 signaling pathway,NFkappaB signaling pathway and G protein coupled receptors signaling pathway.The aim of this study is to explore the expression of RKIP in lung squamous cell carcinoma,and the relationship between RKIP expression and clinical pathology of lung squamous cell carcinoma.Methods The expression of RKIP mRNA w... |
| |
| Keywords: | Lung neoplasms Rafkinase inhibitor protein Metastasis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
