The effect of wall mechanical properties on patency of arterial grafts |
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Authors: | I G Kidson |
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Abstract: | Normal arteries have properties which match the low output impedance of the heart to the high peripheral impedance. These properties can be assessed in terms of compliance (% diameter change per unit pressure change) as well as by other haemodynamic parameters. Experiments were designed using vein, Dacron and expanded polytetrafluoroethylene (PTFE) in a low flow canine femoral artery bypass model. No graft group achieved perfect patency. At twelve weeks 80% of vein grafts, 30% of Dacron grafts, and 15% of PTFE grafts remained patent. The compliance of vein grafts was maintained despite marked thickening of the wall. Patency was correlated at a highly significant level with compliance. The studies demonstrate that the matching of the mechanical properties of grafts to host arteries is important in the design of successful synthetic arterial grafts. |
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