| 肠道菌群对药物代谢影响的研究进展 |
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| 引用本文： | 陈玉艳,王荣,张娟红,鹿辉,李文斌,王昌,孙月梅.肠道菌群对药物代谢影响的研究进展[J].中国药理学通报,2019(2):168-172. |
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| 作者姓名： | 陈玉艳 王荣 张娟红 鹿辉 李文斌 王昌 孙月梅 |
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| 作者单位： | 1.宁夏医科大学药学院;2.兰州军区兰州总医院全军高原环境损伤防治重点实验室 |
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| 基金项目： | 国家科技重大专项(No 2008ZXJ09014-010);国家自然科学基金资助项目(No 81401552;81403004;81673508);全军后勤科研"十二五"重大项目(No AWS14L0005) |
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| 摘 要： | 肠道菌群是寄居在肠道的种类繁多、数量庞大的微生物群落,对药物等外来化合物的代谢至关重要,近年来肠道菌群作为机体"隐形器官"被广泛关注。通过查阅国内外相关文献,该文对机体中肠道菌群的分类、功能及其对中药化学成分和化学药物代谢的影响进行了分析、归纳和总结。了解肠道菌群对药物代谢的影响,明确药物转化过程,对于指导临床合理用药、个体化用药、毒理学评估及推动药物发现和研发具有重要意义,为后期研究高原环境下肠道菌群对药物代谢的影响提供理论指导。
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| 关 键 词： | 肠道菌群 菌群分类 菌群功能 药物代谢 高原低氧 合理用药 |
Effects of intestinal microflora on drug metabolism |
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| CHEN Yu-yan,WANG Rong,ZHANG Juan-hong,LU Hui,LI Wen-bin,WANG Chang,SUN Yue-mei.Effects of intestinal microflora on drug metabolism[J].Chinese Pharmacological Bulletin,2019(2):168-172. |
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| Authors: | CHEN Yu-yan WANG Rong ZHANG Juan-hong LU Hui LI Wen-bin WANG Chang SUN Yue-mei |
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| Institution: | (College of Pharmacy, Ningxia Medical University, Yinchuan 730000,China;Key Lab of the Plateau of EnvironmentalDamage Control, Lanzhou General Hospital of Lanzhou Military Command, Lanzhou730050, China) |
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| Abstract: | A large number of gut flora communities have colonized in the intestine, which is crucial to the metabolism of foreign compounds such as drugs. In recent years, the gut flora has been widely regarded as the “invisible organ” of the body. By reviewing the pertinent literature at home and abroad, classifications and functions of intestinal flora and its influence on the chemical composition and chemical metabolism of Chinese medicine are analyzed in the article. Understanding the impact of intestinal flora on drug metabolism and the process of drug conversion has great significance in guiding clinical rational drug use and individual therapy, evaluating toxicity and promoting drug discovery and development, and providing theoretical guidance for the study of the effects of intestinal flora on drug metabolism in the plateau environment. |
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| Keywords: | intestinal flora flora classification flora function drug metabolism plateau hypoxia rational administration |
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