新疆罗勒挥发油活性成分的网络药理学研究

目的基于网络药理学,研究新疆罗勒挥发油活性成分。方法从不同开源数据库中收集罗勒挥发油的活性成分,预测和筛选出活性成分的作用靶点及其作用的信号通路,构建成分-靶点-通路网络来阐明罗勒挥发油成分对疾病的作用机制。结果筛选出了6个罗勒挥发油活性成分,经成分-靶点-通路网络的分析,发现有25个主要的作用靶点和5个主要的作用通路。结论罗勒挥发油活性成分主要通过5个信号通路作用于皮肤病、癌症、心脑血管疾病等。

Study on active components of volatile oil from Ocimum basilicum L. in Xinjiang

Aim To study the active ingredients of essential oil in Xinjiang Ocimum basilicum L.based on system network pharmacology. Methods Information on the active ingredients of essential oil in Ocimum basilicum L.was collected from different open source databases.The functional targets together with their signaling pathway were predicted and screened.The ingredients,target proteins and their signaling pathways were established to illustrate the functional mechanism of active ingredients of essential oil in Ocimum basilicum L.against the diseases. Results Six active components of basil volatile oil were identified by analyzing the network of ingredient,target and pathway.Twenty-five main functional targets with five major pathways were also recognized. Conclusions The active components of basil essential oil mainly exert their effects on skin diseases,cancer and cardiovascular and cerebrovascular diseases through five signaling pathways.