| 小胶质细胞/巨噬细胞的极化及在脑卒中修复中的作用 |
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| 引用本文： | 朱婷,孙桂波,孟祥宝,董东霞,赵立宇,孙晓波. 小胶质细胞/巨噬细胞的极化及在脑卒中修复中的作用[J]. 中国药理学通报, 2019, 0(8): 1046-1050 |
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| 作者姓名： | 朱婷 孙桂波 孟祥宝 董东霞 赵立宇 孙晓波 |
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| 作者单位： | 1.中国医学科学院北京协和医学院药用植物研究所中药(天然产物)创新药物研发北京市重点实验室;2.哈尔滨商业大学 |
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| 基金项目： | 国家自然科学基金资助项目(No 8177142084);中国医学科学院医学与健康科技创新工程资助项目(No 2016-I2M-1-012) |
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| 摘 要： | 传统上,小胶质细胞/巨噬细胞激活在缺血性脑卒中修复中被认为起有害作用。然而,越来越多的证据表明,小胶质细胞/巨噬细胞激活对于减轻脑缺血后神经细胞凋亡,促进神经发生和促进功能恢复至关重要。目前研究认为,炎症微环境会极大地影响小胶质细胞/巨噬细胞的表型变化,从而使同一脑组织在受损的不同阶段具有不同的基因表达模式和生物功能。该文就小胶质细胞/巨噬细胞活化的机制及可能的潜在疗法进行综述。
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| 关 键 词： | 小胶质细胞/巨噬细胞 脑卒中 极化 M1/M2表型 炎症 治疗 |
Polarization of microglia/macrophages and its role in ischemic stroke repair |
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| ZHU Ting,SUN Gui-bo,Meng Xiang-bao,Dong Dong-xia,ZHAO Li-yu,SUN Xiao-bo. Polarization of microglia/macrophages and its role in ischemic stroke repair[J]. Chinese Pharmacological Bulletin, 2019, 0(8): 1046-1050 |
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| Authors: | ZHU Ting SUN Gui-bo Meng Xiang-bao Dong Dong-xia ZHAO Li-yu SUN Xiao-bo |
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| Affiliation: | (Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences Peking Union Medical College,Beijing Key Lab of Innovative Drug Discovery of Traditional Chinese Medicine(Natural Medicine) and Translational Medicine,Beijing 100193,China;Harbin University of Commerce,Harbin 150000,China) |
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| Abstract: | Traditionally,microglia/macrophage activation is thought to be detrimental in ischemic stroke.However,there is increasing evidence that microglia/macrophage activation is essential for attenuating neuronal apoptosis after cerebral ischemia,promoting neurogenesis and promoting functional recovery.Current research suggests that the inflammatory microenvironment greatly affects the phenotypic changes of microglia/macrophages,so that the same brain tissue has different gene expression patterns and biological functions at different stages of brain damage.This review provides a comprehensive review of the mechanisms of microglia/macrophage activation and the possible potential therapies. |
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| Keywords: | microglia/macrophages ischemic stroke polarization M1/M2 phenotype inflammation treatment |
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