急性脑梗死患者颈动脉粥样硬化斑块及血脂、凝血谱的关系分析

目的探讨急性脑梗死患者颈动脉粥样硬化斑块的发生情况及血脂、凝血谱的关系。方法应用美国惠普公司产SONOS-1000型彩色多普勒超声诊断仪分别对110例急生脑梗死患者和41例对照组颈动脉进行检测,观察颈动脉粥样硬化斑块的发生情况,同时检测血脂、凝血谱。结果(1)急性脑梗死组颈动脉粥样硬化斑块发生率为78.18%,对照组为21.95%,差异有统计学意义(P<0.001)。(2)急性脑梗死组颈动脉粥样硬化斑块好发于颈总动脉分叉处,占62.79%,梗死侧颈动脉粥样硬化斑块发生率高于非梗死侧,差异有统计学意义(P<0.01),侧向符合率82.56%。(3)高血压、高胆固醇、低密度脂蛋白及载脂蛋白B的升高、高纤维蛋白原是急性脑梗死颈动脉粥样硬化斑块的危险因素。结论颈动脉粥样硬化斑块与急性脑梗死之间存在着密切关系,对急性脑硬死患者进行颈动脉超声检查,及早发现颈动脉粥样硬化斑块并积极控制危险因素,对预防和治疗急性脑梗死具有重要意义。

Study on the correlation among carotid artery athermanous plaque, serum lipid and coagulation spectrum in patients with acute cerebral infarction

Objective To investigate the carotid athermanors plaque,serum lipid and coagulation spectrum in 110 cases of acute cerebral infarction(ACI)patients.Methods The carotid artery athermanous plaque was examined by ultrasonography and the serum lipid,coagulation spectrum were measured in 110 patients with ACI and 40 cases of controls.Results (1)The incidence of carotid athermanous plaque was 78.18% in ACI and 21.95% in controls.There were statistic significance(P<0.001)betwcen two groups.(2)The most of athermanous plaque were located in carotid artery furcated(62.79%) especially in the infarction side(P<0.01).(3)Hypertension,high levels of cholesterol,LDL,apolipoprotein B,and fibrinogen were risk factor of carotid athermanous plaque in patients with ACI.Conclusions There are close correlation between carotid athermanous plaque and acute cerebral infarction.Early finding of carotid athermanous plaque by ultrasonography and contorlling of risk factors play a very important role in the prevention and treatment of ACI.