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Brazilian Sepsis Epidemiological Study (BASES study) |
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| Authors: | Eliézer Silva de Almeida Marcelo Pedro Ana Cristina Beltrami Sogayar Tatiana Mohovic Lika de Oliveira Carla Silva Mariano Janiszewski Ruy Guilherme Rodrigues Cal Fernandes Érica de Sousa Thereza Phitoe Abe Joel de Andrade Dias Jorge de Matos Ederlon Rezende Murillo Assunção Álvaro Avezum Patrícia CS Rocha Gustavo Faissol Janot de Matos André Moreira Bento Danielli Alice Corrêa Paulo Cesar Bastos Vieira Elias Knobel |
| Affiliation: | 1. Supervisor, Intensive Care Unit, Hospital Israelita Albert Einstein, S?o Paulo, Brazil 2. Associate Professor, Medical School, Santo Amaro University, S?o Paulo, Brazil 3. Staff Member, Intensive Care Unit, Hospital Israelita Albert Einstein, S?o Paulo, Brazil 4. Resident of Internal Medicine, Medical School, Santo Amaro University, S?o Paulo, Brazil 5. Research Nurse, Intensive Care Unit, Hospital Israelita Albert Einstein, S?o Paulo, Brazil 6. Fellow, Intensive Care Unit, Hospital Israelita Albert Einstein, S?o Paulo, Brazil 7. Head, Intensive Care Unit, University Hospital, Federal University of Santa Catarina, Florianopolis, Brazil 8. Staff Member, Intensive Care Unit, Hospital Governador Celso Ramos, Florianopolis, Brazil 9. Head, Intensive Care Unit, Hospital dos Servidores do Estado, S?o Paulo, Brazil 10. Staff Member, Intensive Care Unit, Hospital dos Servidores do Estado, S?o Paulo, Brazil 11. Research Nurse, Intensive Care Unit, Medical School, Santo Amaro University, S?o Paulo, Brazil 12. Staff Member, Intensive Care Unit, University Hospital, Federal University of Santa Catarina, Florianopolis, Brazil 13. Head, Intensive Care Unit, Medical School, Santo Amaro University, S?o Paulo, Brazil 14. Head, Intensive Care Unit, Hospital Israelita Albert Einstein, S?o Paulo, Brazil |
| Abstract: | IntroductionConsistent data about the incidence and outcome of sepsis in Latin American intensive care units (ICUs), including Brazil, are lacking. This study was designed to verify the actual incidence density and outcome of sepsis in Brazilian ICUs. We also assessed the association between the Consensus Conference criteria and outcomeMethodsThis is a multicenter observational cohort study performed in five private and public, mixed ICUs from two different regions of Brazil. We prospectively followed 1383 adult patients consecutively admitted to those ICUs from May 2001 to January 2002, until their discharge, 28th day of stay, or death. For all patients we collected the following data at ICU admission: age, gender, hospital and ICU admission diagnosis, APACHE II score, and associated underlying diseases. During the following days, we looked for systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic shock criteria, as well as recording the sequential organ failure assessment score. Infection was diagnosed according to CDC criteria for nosocomial infection, and for community-acquired infection, clinical, radiological and microbiological parameters were used.ResultsFor the whole cohort, median age was 65.2 years (49–76), median length of stay was 2 days (1–6), and the overall 28-day mortality rate was 21.8%. Considering 1383 patients, the incidence density rates for sepsis, severe sepsis and septic shock were 61.4, 35.6 and 30.0 per 1000 patient-days, respectively. The mortality rate of patients with SIRS, sepsis, severe sepsis and septic shock increased progressively from 24.3% to 34.7%, 47.3% and 52.2%, respectively. For patients with SIRS without infection the mortality rate was 11.3%. The main source of infection was lung/respiratory tract.ConclusionOur preliminary data suggest that sepsis is a major public health problem in Brazilian ICUs, with an incidence density about 57 per 1000 patient-days. Moreover, there was a close association between ACCP/SCCM categories and mortality rate. |
| Keywords: | epidemiology incidence outcome sepsis |
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