小剂量辛伐他汀在老年人中的调脂疗效

目的观察小剂量辛伐他汀在军队离退休老干部中的调脂疗效及减少心血管事件危险性的作用。方法选择北京军区驻京部分离退休老干部综合干预中TC控制未达标者,且从2002年6月～2006年12月服用辛伐他汀10～20 mg/d的冠心病及其高危患者245例作为辛伐他汀组。同期未进行综合干预、未服用他汀类药物的冠心病及高危患者221例作为对照组,并进行对比分析。结果与基线比较,研究结束时辛伐他汀组TC、LDL C、TG分别下降了21.24%、34.09%和18.44%(P<0.01),HDLC下降了3.10%(P>0.05);对照组TC、LDL-C分别下降了3.11%、4.34%(P<0.05),TG下降了10.50%(P>0.05),HDL-C下降了10.24%(P<0.01)。与对照组比较,辛伐他汀组TC、LDLC分别下降了18.13%、29.75%(P<0.01),TG下降了7.94%(P<0.05),HDL-C上升了7.14%(P<0.01);心血管事件危险性降低了43.21%(P<0.05),脑卒中危险性降低了35.58%(P>0.05)。结论小剂量辛伐他汀在老年血脂异常人群中的调脂效果显著,心血管事件危险性明显降低。

Efficacy of low-dose simvastatin in cholesterol-lowering treatment in elderly

Objective To analyse the efficacy of low-dose simvastatin in cholesterol-lowering treatment in elderly officers and in decreasing the incidence of the cardiovascular diseases.Methods 245 CHD patients or patients with high risk factors for CHD whose cholesterol level had not achieved the target in the study of comprehensive intervention on retired elderly officers were recruited as the simvastatin group and assigned to receive simvastatin 10 or 20 mg/day from June, 2002 to December,2006.At the same time,221 CHD patients or patients with high risk factors for CHD without treatment with statins were recruited as the control group.Results Compared with the levels at baseline,the average levels of TC,LDL-C,and TG were reduced by 21.24%,34.09% and 18.44%(P<0.01),respectively,HDL-C was reduced by 3.10%(P>0.05) at the study endpoint in the simvastatin group,whereas TC,LDL-C,and TG were reduced by 3.11%, 4.34%(P<0.05) and 10.50%(P>0.05),respectively,HDL-C was reduce by 10.24%(P<0.01) in the control group.The levels of TC,LDL-C and TG were reduced by 18.13%,29.75% (P<0.01) and 7.94%(P<0.05),respectively,HDL-C was increased by 7.14%(P<0.01), the relative risk of stroke and cardiovascular events were reduced by 35.58%(P>0.05) and 43.21%(P<0.05) respectively,in the simvastatin group compared with the control group.Conclusion The efficacy of low-dose simvastatin in cholesterol-lowering treatment is significant in elderly,and the treatment can significantly decrease the incidence of cardiovascular events.