| 海洋细菌成团泛菌(Pantoea agglomerans)中环二肽类代谢产物的研究 |
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| 引用本文： | 沈明曦；陈,刚；田,黎；易国卿；杨,硕；裴月湖.海洋细菌成团泛菌(Pantoea agglomerans)中环二肽类代谢产物的研究[J].沈阳药科大学学报,2011,28(5):350-354. |
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| 作者姓名： | 沈明曦；陈 刚；田 黎；易国卿；杨 硕；裴月湖 |
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| 作者单位： | 1. 沈阳药科大学 中药学院,辽宁 沈阳 110016;2. 国家海洋局第一海洋研究所,山东 青岛 266061;3. 石药集团中诺药业有限公司 质量管理部,河北 石家庄 050000 |
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| 基金项目： | 国家“863”发展计划资助项目(2007AA09Z413,2007AA09Z435); 国家自然科学基金资助项目(40776098) |
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| 摘 要： | 目的研究海洋细菌成团泛菌(Pantoea agglomerans)发酵液的乙酸乙酯萃取物中的化学成分,以期得到有活性的先导化合物。方法采用硅胶柱色谱、凝胶柱色谱、高效液相色谱等方法进行分离纯化,通过理化性质和波谱数据分析鉴定化合物的结构。结果从海洋细菌Pantoea agglomer-ans的乙酸乙酯萃取物中分离得到10个环二肽类化合物,分别鉴定为环-(苯丙氨酸-脯氨酸)cy-clo(Phe-Pro),1]、环-(缬氨酸-脯氨酸)cyclo(Val-Pro),2]、环-(丙氨酸-亮氨酸)cyclo(Ala-Leu),3]、环-(色氨酸-脯氨酸)cyclo(Trp-Pro),4]、环-(色氨酸-甘氨酸)cyclo(Trp-Gly),5]、环(4-羟基-脯氨酸-苯丙氨酸)cyclo(4-hydroxyl-Pro-Phe),6]、环-(脯氨酸-酪氨酸)cyclo(Pro-Tyr),7]、环-(亮氨酸-亮氨酸)cyclo(Leu-Leu),8]、环-(脯氨酸-亮氨酸)cyclo(Pro-Leu),9]、环-(缬氨酸-异亮氨酸)cyclo(Val-Ile),10]。结论化合物1~10均为首次从海洋细菌Pantoea agglomerans中分离得到。
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| 关 键 词： | 海洋细菌 成团泛菌 环二肽 化学成分 结构鉴定 |
| 收稿时间： | 2010-9-29 |
| 修稿时间： | 2011-3-20 |
Cyclo-dipeptide metabolites from marine bacterium Pantoea agglomerans |
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| SHEN Ming-xi,CHEN Gang,TIAN Li,YI Guo-qing,YANG Shuo,PEI Yue-hu.Cyclo-dipeptide metabolites from marine bacterium Pantoea agglomerans[J].Journal of Shenyang Pharmaceutical University,2011,28(5):350-354. |
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| Authors: | SHEN Ming-xi CHEN Gang TIAN Li YI Guo-qing YANG Shuo PEI Yue-hu |
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| Institution: | 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. The First Institute of Oceanography SOA, Qingdao 266061, China; 3. Quality Assurance Dept.CSPC Zhongnuo Pharmaceutical, Shijiazhuang 050000, China |
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| Abstract: | Objective To isolate and identify the chemical constituents from marine bacterium Pantoea agglomerans. Methods The compounds from the ethyl acetate extracts were isolated by silica gel column, Sephadex LH-20 column chromatography and HPLC techniques. And these compounds were identified by the physico-chemical properties and spectral analysis. Results Ten compounds were isolated from the ethyl acetate extracts of marine bacteria Pantoea agglomerans. They were identified as cyclo(Phe-Pro)(1), cyclo(Val-Pro)(2), cyclo(Ala-Leu)(3), cyclo(Trp-Pro)(4), cyclo(Trp-Gly)(5), cyclo (4-hydroxyl-Pro-Phe)(6), cyclo(Pro-Tyr)(7), cyclo(Leu-Leu)(8), cyclo(Pro-Leu)(9), cyclo(Val-Ile)(10). Conclusion All of the compounds are isolated from the marine bacterium Pantoea agglomerans for the first time. |
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| Keywords: | marine bacterium Pantoea agglomerans" target="_blank">Pantoea agglomerans')">Pantoea agglomerans cyclo-dipeptide chemical constituent structure identification |
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