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| 基于AVP-cAMP-AQP_2探讨黄柏及其不同炮制品的滋阴作用 | |
| 引用本文： | 廉 莲 ；贾天柱. 基于AVP-cAMP-AQP_2探讨黄柏及其不同炮制品的滋阴作用[J]. 沈阳药科大学学报, 2011, 28(5): 400-404 |
| 作者姓名： | 廉 莲 ；贾天柱 |
| 作者单位： | （1. 辽宁科技学院,辽宁 本溪 117004; 2. 辽宁中医药大学 药学院,辽宁 大连 116600） |
| 摘 要： | 目的研究黄柏及其不同炮制品的滋阴作用。方法以黄柏及其不同炮制品的提取物灌胃,观察大鼠的尿量、尿渗透压的变化,检测大鼠血中皮质醇、cAMP和AVP含量,并对大鼠髓质水通道蛋白2免疫组化。结果黄柏及其不同炮制品均能提高阴虚模型大鼠的尿量,降低尿渗透压;降低阴虚模型大鼠血液中的皮质醇、cAMP和AVP含量;能提高肾阴虚模型大鼠肾脏的APQ2表达。结论黄柏及其炮制品均具有不同程度的滋阴作用。 |
| 关 键 词： | 黄柏 滋阴 水通道蛋白2 抗利尿激素 环磷酸腺苷 |
| 收稿时间： | 2010-12-28 |
| 修稿时间： | 2011-03-09 |
Study on the effects of nourishing Yin of Phellodendron chinense and its different processed products based on the AVP-cAMP-AQP2 |
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| LIAN Lian,JIA Tian-zhu. Study on the effects of nourishing Yin of Phellodendron chinense and its different processed products based on the AVP-cAMP-AQP2[J]. Journal of Shenyang Pharmaceutical University, 2011, 28(5): 400-404 | |
| Authors: | LIAN Lian JIA Tian-zhu |
| Affiliation: | 1. Liaoning Institute of Science and Technology, Benxi 117004, China; 2. School of Pharmacy, Liaoning Universary of Traditional Chinese Medicine, Dalian 116600, China |
| Abstract: | Objective To study the effects of nourishing Yin(a term of traditional Chinese medicine)of Phellodendron chinense and its different processed products.Methods Decoction of Phellodendron chinense and its different processed products were given to rats.The urine volume and urine osmotic pressure changes of rats were studied,and the contents of cortisol,cAMP(cyclic adenosine monophosphate)and AVP(arginine vasopressin)in the blood of rats were detected,and immunohistochemical results about the medulla AQP2(aquaporin-2,AQP2)of rat were analyzed.Results The rusults showed that Phellodendron chinense and its different processed products can improve the urine output of Yin deficiency rat,lower urine osmotic pressure,reduce the contents of cortisol,cAMP and AVP in the blood of Yin deficiency rat,and improve APQ2 expression.Conclusions Phellodendron chinense and its different processed products have the effects of nourishing Yin. |
| Keywords: | Phellodendron chinense')" >Phellodendron chinense nourishing-Yin 2')" >AQP2 AVP cAMP |
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