Treatment of chronic experimentalStaphylococcus aureus osteomyelitis with LY146032 and vancomycin |
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| Authors: | Q. N. Luu T. B. Buxton D. R. Nelson J. P. Rissing |
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| Affiliation: | (1) Mercer School of Medicine, 1500 Coleman Avenue, 31298 Macon, Georgia, USA;(2) Veterans Administration Medical Center, Infectious Disease Laboratory and the Medical College of Georgia, 30910 Augusta, Georgia, USA;(3) Dublin Internal Medicine, Inc., 606 Academy, 31021 Dublin, Georgia, USA |
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| Abstract: | LY146032 and vancomycin were compared as therapeutic agents in the treatment of chronicStaphylococcus aureus osteomyelitis in the rat. Quantitative cultures disclosed that one of 16, none of 16, and two of 17 tibiae were sterile from the control, LY146032, and vancomycin groups, respectively. From positive cultures, geometric mean staphylococcal CFU per gram of bone were as follows: control, 5.13±1.58; LY146032, 5.36±0.43 (p=0.57); and vancomycin, 4.33±1.73 (p=0.078). Mean gross pathology was decreased significantly in both treatment groups. LY146032 was no more effective than vancomycin in reducing bacterial counts. |
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