L细胞分泌的肽类激素 |
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引用本文: | 吕雪欣.L细胞分泌的肽类激素[J].黑龙江医学,2012(12):919-925. |
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作者姓名: | 吕雪欣 |
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作者单位: | 天津市泰达医院 |
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摘 要: | L细胞作为肠道内分泌细胞的一种,零散分布于胃肠道,分泌胰高血糖素样肽1、胰高血糖素样肽2、多肽YY等多种重要的肽类激素。胰高血糖素样肽1对脂肪细胞、PDX-1基因的调控、改善内质网应激、细胞凋亡、神经系统、消化系统、血管内皮、糖调节等均有作用。而胰高血糖素样肽2目前主要了解其对肠道作用突出。多肽YY对肝癌细胞的增殖有抑制作用,对食欲也有影响,这些还需要更细致的深入研究。
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关 键 词: | 胰高血糖素 胰高血糖素样肽 Langerhans细胞 |
Peptide Hormones Scattered by L Cells |
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Institution: | Lü Xue-xin(Tianjin Taida Hospital,Tianjin 300457,CHINA) |
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Abstract: | L cells is a kind of endocrine cells in the gut,scattering in the gastrointestinal tract and secreting glucagon-like peptide-1(GLP-1),glucagon like peptide-2(GLP-2),peptide YY(PYY) and other important peptide hormones.They have their own physiological characteristics.The glucagon-like peptides 1(GLP-1) has effect on fat cells,regulation of the PDX-1 gene,improvement of endoplasmic reticulum stress,apoptosis,nervous system,digestive system,endothelial and glucose regulation.While the glucagon like peptide-2(GLP-2) has main effect on intestinal function highlights.Polypeptide YY not only has effect on hepatocellular carcinoma cell proliferation,but also plays a role in appetite.Detailed research is needed. |
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Keywords: | Glucagons Glucagon like peptide Langerhans cells |
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