血管内皮生长因子与病理性脉络膜新生血管

脉络膜新生血管(choroidal neovascularization,CNV)是造成许多眼底疾病和视力严重下降的主要原因。而血管内皮生长因子(vascular endothelial growth factor,VEGF)与CNV的形成密切相关,VEGF的过度表达将导致CNV形成。抗VEGF治疗能有效抑制CNV形成,从而达到治疗效果。本文就VEGF在眼内的分布及其在病理性CNV生成中的表达,和病理性CNV抗VEGF治疗的研究现状做一综述。

Vascular endothelial growth factor and pathological choroidal neovascularization

Choroidal neovascularization(CNV) is the main cause for serious reduction of visual acuity and a number of eye diseases.The vascular endothelial growth factor(VEGF) is closely related to the formation of CNV,and over-expression of VEGF will lead to the formation of CNV.Anti-VEGF treatment can effectively inhibit the formation of CNV to achieve therapeutic effect.This article reviews distribution of VEGF in the eyes,its expression and anti-VEGF treatment in pathological CNV.