地氯雷他定治疗慢性荨麻疹疗效观察

目的 :观察地氯雷他定治疗慢性荨麻疹的疗效和安全性。方法 :采取随机对照临床试验 ,试验组每日口服一片地氯雷他定 (每片 5mg) ,疗程 1 4d;对照组每日口服一片西替利嗪 (每片 1 0mg) ,疗程 1 4d。结果 :共治疗 85例 ,试验组 4 3例 ,对照组 4 2例。总有效率试验组为 88 37% ,对照组为80 95 % ,两组比较差异无显著性 (P >0 0 5 )。不良反应发生率试验组为 9 30 % ,对照组为 1 9 0 5 % ,两组比较差异无显著性 (P >0 0 5 )。结论 :地氯雷他定是一种治疗慢性荨麻疹有效安全的药物。

Investigation on the Therapeutic Effect of Desloratidine in Treatment of Chronic Urticaria

Objective:To observe the clinical efficacy and safety of desloratidine in treatment of chronic urticaria. Methods:A randomly comparative study was conducted. The patients were randomly divided into two groups: received desloratidine (5 mg) or cetirizine (10 mg) once daliy for 14 days. Results: 85 patients completed the trial, including 43 cases in desloratidine group and 42 cases in cetirizine group. The effective rate of desloratidine and cetrizine were 88.37% and 80.95% respectively, No statistically significance was observed between tow groups (P>0.05) after 14 days treatment. The incidences of adverse reaction of desloratidine and cetirizine were 9.3% and 19.05% respectively, There were no statiastically significance between two groups (P>0.05). Conclusion:Desloratidine is a effective agent in the treatment of chronic urticaria.