| 扩血管药对大鼠急性缺氧性肺动脉高压的影响——川芎嗪、汉防己甲素、酚苄明及酚妥拉明的作用 |
| |
| 引用本文： | 邹爱平,王迪浔,吴锋. 扩血管药对大鼠急性缺氧性肺动脉高压的影响——川芎嗪、汉防己甲素、酚苄明及酚妥拉明的作用[J]. 华中科技大学学报(医学版), 1984, 0(4) |
| |
| 作者姓名： | 邹爱平 王迪浔 吴锋 |
| |
| 作者单位： | 武汉医学院基础医学部病理生理学教研室(邹爱平，王迪浔)，武汉医学院基础医学部病理生理学教研室(吴锋) |
| |
| 摘 要： | 川芎嗪(80mg/kg体重)及酚苄明(0.25mg/kg体重)扩张肺血管,增加心输出量,抑制缺氧性肺血管收缩,而且对体循环的影响较小;汉防已甲素(1.85mg/kg体重)减慢心率,降低体肺循环压力及阻力,也能减弱缺氧性肺血管收缩;酚妥拉明虽然迅速降低体肺循环的压力和阻力,但不能减弱缺氧性肺血管收缩。这提示川芎嗪及酚苄明对缓解肺动脉高压,改善心功能可能疗效较好。
|
| 关 键 词： | 川芎嗪 汉防己甲素 缺氧 肺动脉高压 |
Hemodynamic Effects of Ligustrazine, Tetrandrihe, Phentolamine and Phenoxybenzamine on Pulmonary Circulation During Alveolar Hypoxia |
| |
| Zou Aiping,Wang Dixun,Wu Feng. Hemodynamic Effects of Ligustrazine, Tetrandrihe, Phentolamine and Phenoxybenzamine on Pulmonary Circulation During Alveolar Hypoxia[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1984, 0(4) |
| |
| Authors: | Zou Aiping Wang Dixun Wu Feng |
| |
| Affiliation: | Zou Aiping,Wang Dixun,Wu FengDepartment of Pathophysiology,Faculty of Basic Medical Sciences,Wuhan Medical College,Wuhan |
| |
| Abstract: | The hemodynamic effects of ligustrazine, tetrandrine, phentolamine and phenoxybenzamine on pulmonary circulation were studied. Ligustrazine(80mg/kg)and phenoxybenzamine (0.25mg/kg) dilated pulmonary vessels, increased cardiac output and inhibited hypoxic pulmonary vasoconstriction as well as dilated slightly systemic vessels. Tetrandrine (1.85mg/kg) reduced not only pulmonary vascular resistance and weakened hypoxic pulmonary vasoconstriction, but also slowed down heart rate and decreased systemic vascular resistance. Phentolamine reduced significantly pulmonary and systemic vascular resistance but did not weaken hypoxic pulmonary vasoconstriction. The results suggest that ligustrazine and phenoxybenzamine could more evidently relax pulmonary hypertension and improve cardiac function than phentolamine and tetrandrine. |
| |
| Keywords: | Ligustrazine Tetrandrine hypoxia pulmonary hypertension |
| 本文献已被 CNKI 等数据库收录！ |
|
