SERT and DAT availabilities under citalopram treatment in obsessive-compulsive disorder (OCD). |
| |
| Authors: | Oliver Pogarell Gabriele Poepperl Christoph Mulert Christine Hamann Nikolai Sadowsky Michael Riedel Hans-Juergen Moeller Ulrich Hegerl Klaus Tatsch |
| |
| Institution: | Department of Psychiatry, Section of Clinical Neurophysiology, Ludwig-Maximilians-University of Munich, Nussbaumstr. 7, D-80336 Munich, Germany. oliver.pogarell@med.uni-muenchen.de |
| |
| Abstract: | Serotonin and dopamine transporter (SERT, DAT) availabilities have prospectively been investigated using 123I]beta-CIT and single photon emission computed tomography in subjects with obsessive-compulsive disorder under treatment with the selective serotonin reuptake inhibitor citalopram. SERT availability decreased by a mean 36.5%, whereas DAT availability increased by about 40%. The data point at a citalopram induced modulation of both serotonergic and dopaminergic activity and support the notion of functional interactions of monoaminergic systems in the human brain. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
