常规易测检验指标与慢性乙肝中医证型相关性研究

目的探讨慢性乙肝患者常规易测检验指标与中医辨证论治的关系。方法筛选出湿热中阻、肝郁脾虚、肝肾阴虚、脾肾阳虚、瘀血阻络五组证型慢性乙肝患者各35例，同时选择健康人25名作为对照组。检测全血红细胞平均体积（MCV）、红细胞分布宽度（RDW）、血小板（PLT）、血小板平均体积（MPV）等指标。结果①红细胞参数：RDW：湿热中阻型、瘀血阻络型分别与对照组、肝郁脾虚型、肝肾阴虚型、脾肾阳虚型比较差异有统计学意义（P〈0．01）。MCV ：湿热中阻型、瘀血阻络型与对照组比较差异有统计学意义（P〈0．05）。②血小板参数：PLT：湿热中阻型、瘀血阻络型分别与对照组、肝肾阴虚型、脾肾阳虚型比较差异有统计学意义（P〈0．01）。肝郁脾虚型与对照组比较（P〈0．01），与肝肾阴虚型、脾肾阳虚型比较差异均有统计学意义（P〈0．05）。MPV：湿热中阻型、瘀血阻络型分别与对照组、肝肾阴虚型、脾肾阳虚型比较差异有统计学意义（P〈0．01）。肝郁脾虚型与对照组比较差异有统计学意（P〈0．05）。结论红细胞参数MCV／RDW、血小板参数PLT／MPV四种指标与慢性乙肝证型有一定相关性，以瘀血阻络型最甚、湿热中阻型次之，可作为慢性乙肝中医辨证分型的参考依据。

Study on the relationship between conventional easy measuring inspection index and chronic hepatitis B traditional chinese medicial types of syndrome

Objective To analyze the relationship between conventional easy measuring inspection indxes and chronic hepatitis B traditional Chinese medicial syndrome pattern. Methods Five groups of thirty-five patients both in wards and clinics are selected respectively, including accumulation of heat and dampness group, liver depression and spleen deficiency group, yin deficiency of liver and kidney group, yang deficiency of spleen and kidney group, qi stagnant blood stasis group. At the same time twenty-five healthy subjects are selected as control group. Whole blood mean corpuscular volume （MCV）, red blood cell volume distribution width （RDW）, platelet （PLT）, mean platelet volume （MPV） levels have been detected. Results ①Red blood cell parameters. RDW： statistical significance has shown be- tween accumulation of heat and dampness group, qi stagnant blood stasis group and control group, liver depression and spleen deficiency group, yin deficiency of liver and kidney group, yang deficiency of spleen and kidney group respec- tively （P 〈 0.01）. MCV： Compared to control group, accumulation of heat and dampness group, qi stagnant blood stasis group witness statistical difference （P 〈 0.05）. ②Platelet parameters. PLT： there is statistical significance between ac- cumulation of heat and dampness group, qi stagnant blood stasis group and control group, yin deficiency of liver and kidney group, yang deficiency of spleen and kidney group （P 〈 0.01）. Compared to control group, liver depression and spleen deficiency group has statistical difference （P 〈 0.01）. In eomparision with yin deficiency of liver and kidney group, yang deficiency of spleen and kidney group, liver depression and spleen deficiency group also has statistical dif- ference （P 〈 0.05）. MPV： there is statistical significance between accumulation of heat and dampness group, qi stag- nant blood stasis group and control group, yin deficiency of liver and kidney group, yang deficiency of spleen and kid- ney group （P 〈 0.01）. Compared to control group, liver depression and spleen deficiency group has statistical difference （P 〈 0.05）. Conclusion There is certain relationship between the following four indexes, including red blood cell pa- rameters MCV/RDW, platelet parameters PLT/MPV and chronic hepatitis B traditional Chinese medicial syndrome pattern, with qi stagnant blood stasis the most obvious, accumulation of heat and dampness coming next. Therefore, they can be taken as reference basis for syndrome pattern differentiation in chronic hepatitis B.