活血退黄汤联合血浆置换治疗重型肝炎60例临床观察

目的观察活血退黄汤联合血浆置换治疗重型肝炎的临床疗效。方法将120例重型肝炎患者随机分为2组。2组均采用常规基础疗法,对照组60例联合应用血浆置换治疗,治疗组60例在对照组治疗基础上同时口服活血退黄汤。2组均以4周为1个疗程,1个疗程结束后观察临床疗效及治疗前后肝功能主要指标和凝血酶原活动度(PTA)。结果治疗组总有效率91.67%,对照组总有效率75.00%,2组比较差异有统计学意义(P0.05),治疗组临床疗效优于对照组。2组治疗前后总胆红素(TBiL)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)和凝血酶原活动度(PTA)比较差异均有统计学差异(P0.05),治疗组改善优于对照组。结论活血退黄汤联合血浆置换治疗重型肝炎疗效确切。

Observation of Huoxue Tuihuang decoction combined with plasma exchange for the treatment of severe hepatitis

Objective To observe the effect of Huoxue Tuihuang decoction combined with plasma exchange for the treatment of severe hepatitis. Methods 120 patients with severe hepatitis were randomly divided into two groups. Patients in two groups are the basis of conventional therapy, cases in the control group （n=60） treated by plasma exchange treatment, patients in the treatment group were treated by oral Huoxue Tuihuang decoction. A therapeutic course was four weeks in two groups. The clinical efficacy after a course and the main indicators of liver function were observed before and after treatment. Results The total effective rate in treatment group （91.67%） was higher than that in control group （75.00%, P0.05）. There were significant differences between before and after treatment on TBiL, ALT, AST, TC and TT in two groups （P〈0.05）. There was difference between two groups on TBiL, ALT, AST, TC and TT after treatment （P〈0.05）. The improvement of liver function in treatment group was superior to that in control group. Conclusion Huoxue Tuihuang decoction combined with plasma exchange has definite effect on the treatment of severe hepatitis.