Use of stable isotopic tracers in studies of whole body calcium metabolism |
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Authors: | Yergey A L Vieira N E Abrams S A Marini J Goans R E |
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Institution: | Laboratory of Theoretical and Physical Biology and the Human Genetics Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. |
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Abstract: | Stable isotopic tracers of calcium have been used to characterize the absorption of dietary calcium and the subsequent distribution of this element through the body. For a group of 7 healthy children, ages 4-14, and 7 children with osteogenesis imperfecta (OI), types I, III and IV, ages 6-17, there were no detectable differences in the fractional absorption of dietary calcium, 0.29+/-0.11 and 0.28+/-0.16, respectively. The total exchangeable pool of calcium was found to be 161+/-52 mg/kg for the healthy children and 95+/-29 mg/kg for the 3 children with Type I OI, 250+/-75 mg/kg for the 3 children with Type III OI and 216 mg/kg for the child with Type IV OI. |
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