小儿紫绀型先天性心脏病血浆MDA和血液流变学变化

测定３５例青紫型先天性心脏病患儿红细胞、血浆丙二醛（ＭＤＡ）含量、红细胞膜微粘度及血液流变学指标。结果患儿红细胞、血浆ＭＤＡ、膜微粘度、全血粘度、经细胞比积、红细胞聚集指数、刚性指数均显著高于正常组；ＭＤＡ含量，膜微粘度、红细胞刚性指数、聚集指数及全血粘度之间均存在正相关关系。提示患儿红细胞脂质过氧化反应增强，导致膜流动性降低、红细胞变形性差，聚集性增加，可能是血液粘度增加较为主要的原因。

Changes of Plasma MDA and Blood Hemorrheology in Children with Cyanotic Congenital Heart Disease

alondiadehyde(MDA) of erythrocyte and plasma ,erythrocytic membrane microviscosity,and parameters of hemorrheology were determined in 35 children with Cyanotic Congenital Heart Disease(CCHD) and compared with 3 6 normal children.The results showed that the MDA lev-els,microviscosity,whole blood viscosity,erythrocytic rigidity and aggregation were significantly increased in the patients than those in the normal children.There were positive correlations be-tween these parameters above in the patients.The findings indicate that the injury from lipid per-oxidation on erythrocyte membrane , which causes lower ervthrocvtic membrane fluidity and de-formability. may be one of main causes inducing higher blood viscosity in CCHD.