BCL6 rearrangement in a patient with mantle cell lymphoma |
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| Authors: | I Miura A Ohshima A Chubachi T Nimura A Komatsuda S Utsumi M Saito T Machii S Nakamura M Seto A B Miura |
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| Institution: | (1) Third Department of Internal Medicine, Akita University School of Medicine, 1–1–1 Hondo, Akita 010, Japan, JP |
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| Abstract: | We describe a patient with mantle cell lymphoma (MCL) associated with BCL6 gene rearrangement. MCL is a distinct subtype
of non-Hodgkin's lymphoma characterized by CD5+, CD10–, CD20+, t(11;14)(q13;q32) and PRAD1/cyclin D1 overexpression. Although
rearrangement of the BCL6 gene is the most frequent genetic change among diffuse lymphomas and some follicular lymphomas this
is the first report of a patient with MCL associated with BCL6 rearrangement.
Received: 6 January 1997 / Accepted: 17 February 1997 |
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| Keywords: | Mantle cell lymphoma (MCL) BCL6 |
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