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Synthesis of some quaternary ammonium alkylating agents and their effects on soman-inhibited acetylcholinesterase |
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| Authors: | A P Gray R D Platz T C Chang T R Leverone D A Ferrick D N Kramer |
| Abstract: | A number of compounds were synthesized and tested for their ability to realkylate the phosphonate anion of "aged", soman-inhibited acetylcholinesterase. None were found able to do so, but two of the compounds in particular, [2-(4-pyridyl)ethyl]diethylmethylammonium iodide (6) and its 2-isomer 7, proved able to slow the rate of aging significantly. |
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