| P120-catenin和E-cadherin的协同表达与肺癌的恶性程度相关 |
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| 引用本文： | 张迪,刘洋,王恩华. P120-catenin和E-cadherin的协同表达与肺癌的恶性程度相关[J]. 解剖科学进展, 2009, 15(2): 129-133 |
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| 作者姓名： | 张迪 刘洋 王恩华 |
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| 作者单位： | 中国医科大学,病理学教研室,辽宁,沈阳,110001 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的方法结果结论探讨p120-catenin(p120ctn)和E-cadherin(E-cad)在非小细胞肺癌中的表达是否具有相关性。方法免疫组织化学S-P法、RT-PCR及WesternBlot等检测肺癌组织中p120ctn和E-cad的表达情况。结果p120ctn和E-cad在肺癌组织中的表达明显低于正常肺组织,并且p120ctn的异常表达与E-cad的异常表达呈正相关。肺癌组织中p120ctn和E-cad的异常表达与肺癌的高分期,低分化和淋巴结转移明显相关。与正常支气管上皮细胞HBE相比,同源的BE1和LH7细胞中都显示出p120ctn、E-cad的表达下降。但在转移能力较高的BE1细胞系中这种异常表达的现象尤为明显。结论肺癌中p120ctn和E-cad的低表达可能与肺癌的恶性度有关。
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| 关 键 词： | 肺癌 p120-catenin E-cadherin |
Abnormal Expression of p120-catenin and E-cadherin is Significantly Associated with Malignant Phenotype of Human Lung Cancer |
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| ZHANG Di,LIU Yang,WANG En-hua. Abnormal Expression of p120-catenin and E-cadherin is Significantly Associated with Malignant Phenotype of Human Lung Cancer[J]. Progress of Anatomical Sciences, 2009, 15(2): 129-133 |
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| Authors: | ZHANG Di LIU Yang WANG En-hua |
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| Affiliation: | Department of Pathology;China Medical University;Shenyang 110001 China |
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| Abstract: | Objective To explore the relationships between the expressions of p120-catenin(p120ctn)and E-cadherin(E-cad) in non-small cell lung cancer. Methods Immunohistochemistry S-P method, RT-PCR and Western Blot were used to detect the expressions of p120ctn and E-cadherin in lung cancer tissue. Results The levels of p120ctn and E-cadherin expressions in lung tissues were significantly lower than those in the normal lung tissue, and there were positive correlation between their abnormal expressions and significant... |
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| Keywords: | p120-catenin E-cadherin |
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