| 阿柔比星A聚乳酸毫微粒冻干针剂的研制及体外药物释放规律的研究 |
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| 引用本文： | 蒋学华,何林. 阿柔比星A聚乳酸毫微粒冻干针剂的研制及体外药物释放规律的研究[J]. 中国抗生素杂志, 2000, 25(5): 359-361 |
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| 作者姓名： | 蒋学华 何林 |
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| 作者单位： | 1. 华西医科大学药学院,成都610041
2. 四川省人民医院药剂科,成都610072 |
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| 基金项目： | 国家自然科学基金资助项目!(合同号 :39570 842 ),国家医药技术创新博士项目!(合同号 :95- B- 0 9) |
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| 摘 要： | 研究阿柔比星Ａ聚乳酸毫微粒（ＡＣＲＢ－Ａ－ＰＬＡ－ＮＰ）冻干针剂的制备,并对其体外释药进行考察。根据低共熔点测定结果,以及外观、色泽、再分散性等质量参数为指标,制备出ＡＣＲＢ－Ａ－ＰＬＡ－ＮＰ冻干针剂,采用动脉透析法研究其体个释放规律。结果,制得的ＡＣＲＢ－ＡＰＬＡ－ＮＰ冻干针剂色泽均匀,再分散性良好。其体外释药可用３种方式表达。提示ＡＣＲＢ－Ａ－ＰＬＡ－ＮＰ冻干针剂有明显的缓释特征。
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| 关 键 词： | 阿柔比星A 聚乳酸 毫微粒 冻干针剂 体外释药 |
| 修稿时间： | 1999-03-16 |
Preparation of lyophlized aclarubicin A poly-lactide nanoparticle for injection and the study on the drug releasing mechanism |
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| Jiang Xue-hua,He Lin. Preparation of lyophlized aclarubicin A poly-lactide nanoparticle for injection and the study on the drug releasing mechanism[J]. Chinese Journal of Antibiotics, 2000, 25(5): 359-361 |
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| Authors: | Jiang Xue-hua He Lin |
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| Abstract: | The preparation of lyophlized aclarubicin A poly- lactide nanoparticle for injection and the drug releasing mechanism in vitro were studied.The lyophlization conditions such as the eutetic point,the color and the cake forming as well as the reconstitution properties were determined;and the drug releasing mechanism in vitro was conducted by dynamic dialysis experimental process.Results showed that the lyophlized producthad a good appearance and easily reconstituted in the injection media;while the in vitro drug releasing mechanism could be expressed in the combined three formulas of fit,and manifested itself a significant characteristic of sustained release properties. |
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| Keywords: | Aclarubicin A Poly- lactide Nanoparticle Lyophlization Drug releasing |
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