| 小剂量纳洛酮对吗啡致大鼠依赖和耐受的影响 |
| |
| 引用本文： | 高明龙,刘永哲,张宏,孙永海.小剂量纳洛酮对吗啡致大鼠依赖和耐受的影响[J].军医进修学院学报,2009,30(2):130-132. |
| |
| 作者姓名： | 高明龙 刘永哲 张宏 孙永海 |
| |
| 作者单位： | 1. 北京军区总医院麻醉科,北京,100700
2. 解放军总医院麻醉手术中心,北京,100853 |
| |
| 基金项目： | 军队医药卫生科研基金 |
| |
| 摘 要： | 目的：探讨小剂量纳洛酮对吗啡致大鼠耐受和依赖的影响。方法：18只SD大鼠随机分为3组（n=6），即吗啡对照组（M组，皮下注射6mg／kg的吗啡），吗啡复合纳洛酮组（MN1组，皮下注射6mg/kg吗啡和100ng／kg纳洛酮；MN2组，皮下注射6mg／kg吗啡和10ng／kg纳洛酮）。注射药物30min进行痛阈测定，并进行8d条件性位置偏爱（CPP）训练，最后一次注药后24h进行CPP测定。结果：与训练前比较，训练后在黑箱内停留的时间显著延长（P〈0．01），与M组比较，MN1和MN2组CPP评分显著降低（P〈0．01）；与前3d比较，M组大鼠痛阈在从第4天开始显著下降（P〈0．01），MN1和MN2组痛阈下降值有显著差异。结论：10ng／kg～1μg／kg的纳洛酮能显著抑制应用吗啡后大鼠耐受和依赖的形成。
|
| 关 键 词： | 吗啡 纳洛酮 药物依赖 药物耐受 |
Effects of low dose naloxone on morphine-induced tolerance and dependence in rats |
| |
| GAO Ming-long,LIU Yong-zhe,ZHANG Hong,SUN Yong-hai.Effects of low dose naloxone on morphine-induced tolerance and dependence in rats[J].Academic Journal of Pla Postgraduate Medical School,2009,30(2):130-132. |
| |
| Authors: | GAO Ming-long LIU Yong-zhe ZHANG Hong SUN Yong-hai |
| |
| Institution: | 1.Department of Anesthesiology;Beijing Army General Hospital;Beijing 100700;China;2.Anesthesia and Operation Center;Chinese PLA General Hospital;Beijing 100853;China |
| |
| Abstract: | Objective:To investigate the effects of low dose naloxone on morphine-induced tolerance and dependence in rats.Methods:Eighteen adult male Sprague-Dawley rats were randomly assigned into group M,group MN1,and group MN2(n=6).Rats in group M received 6mg/kg of morphine.Rats in groups MN1 and MN2 were given different doses of naloxone(100ng/kg,10ng/kg)with 6mg/kg of morphine.Pain threshold was determined at thirty minutes after subcutaneous injection of morphine or mixture of morphine and naloxone.Training of ... |
| |
| Keywords: | morphine naloxone drug dependence drug tolerance |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
