High-dose growth hormone (GH) treatment in prepubertal GH-deficient children |
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| Authors: | S Yokoya K Araki Y Igarashi H Kohno Y Nishi Y Hasegawa K Fujita N Iwatani K Tachibana Y Ohyama Y Seino M Satoh K Fujieda T Tanaka |
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| Affiliation: | Department of Pediatrics;Toranomon Hospital, Tokyo, Department of Pediatrics;Kochi Medical School, Kochi, Department of Pediatrics;Tohoku University, Sendai, Department of Endocrinology and Metabolism;Fukuoka Children's Hospital, Fukuoka, Department of Pediatrics;Hiroshima Red-Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima, Department of Endocrinology and Metabolism;Tokyo Metropolitan Kiyose Children's Hospital, Tokyo, Department of Pediatrics;Osaka City General Hospital, Osaka, Department of Pediatrics;Kumamoto University, Kumamoto, Department of Endocrinology and Metabolism;Kanagawa Children's Medical Center, Yokohama, Department of Pediatrics;Kitasato University, Sagamihara, Department of Pediatrics;Okayama University, Okayama, Department of Pediatrics;Toho University, Tokyo, Department of Pediatrics;Hokkaido University, Sapporo, and Division of Endocrinology and Metabolism National Children's Hospital, Tokyo, Japan |
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| Abstract: | Yokoya S, Araki K, Igarashi Y, Kohno H, Nishi Y, Hasegawa Y, Fujita K, Iwatani N, Tachibana K, Ohyama Y, Seino Y, Satoh M, Fujieda K, Tanaka T. High-dose growth hormone (GH) treatment in prepubertal GH-deficient children. Acta Pædiatr 1999; Suppl 428: 76–9. Stockholm. ISSN 0803–5326
Two clinical studies were conducted to determine the effect of different doses of growth hormone (GH) on prepubertal growth in GH-deficient boys. In one study, GH doses of 1.0 and 1.5 IU/kg/week (0.33 and 0.5 mg/kg/week) were given to groups of five children and compared with a conventional Japanese dose of 0.5 IU/kg/week (0.17 mg/kg/week) in 15 children. A significant dose-dependent increase in height velocity occurred in the first year of treatment, but differences between doses were not significant thereafter. In a second study, GH was administered to ten boys at a dose of 0.5 IU/kg/week for the first year, 0.75 IU/kg/week for the second year, 1.0 IU/kg/week for the third year and 0.5 IU/kg/week for the fourth and subsequent years (0.17, 0.25, 0.33 and 0.17 mg/kg/week, respectively). During the second and third years of GH treatment, these boys had significantly higher growth rates than controls, who were given GH at 0.5 IU/kg/week (0.17 mg/kg/week) throughout, indicating successful reduction in'waning'of the treatment effect. At the end of the fourth year, the different protocols from the two studies had both resulted in a greater height SDS than the controls, and did not advance bone maturation. In conclusion, these protocols may be effective in increasing prepubertal height gain in children with GH deficiency. □ Growth hormone, growth hormone deficiency, high dose |
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