| KAI-1基因在晚期肾癌中表达降低 |
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| 引用本文： | 孔宪国,张元芳,丁强,王忠,黄国华.KAI-1基因在晚期肾癌中表达降低[J].癌症,2000,19(6). |
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| 作者姓名： | 孔宪国 张元芳 丁强 王忠 黄国华 |
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| 作者单位： | 1. 上海铁道大学附属铁路医院泌尿外科,上海,200072
2. 上海医科大学华山医院泌尿外科,上海,200040 |
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| 摘 要： | 目的：探讨ＫＡＩ－１ｍＲＮＡ在肾细胞癌中的表达及与浸润转移的关系。方法：采用ＲＴ－ＰＣＲ方法检测３５例肾癌及癌周正常肾组织ＫＡＩ－１ｍＲＮＡ的表达。结果：肾癌组织中ＫＡＩ－１表达率明显低于癌周正常组织（Ｐ＜０.０５）；有肾周浸润或局部淋巴结转移的患者（Ⅲ、Ⅳ期）骨癌组织中ＫＡＩ－１表达明显低于Ⅰ、Ⅱ期患者（Ｐ＜０．０５）。结论：ＫＡＩ-１基因的低表达可能与肾细胞癌的进展有关。
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| 关 键 词： | 肾肿瘤 KAI-1 转移 |
Decreased KAI-1 expression in advanced renal cell carcinoma |
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| KONG Xian-guo,ZHANG Yuan-fang,DING Qiang,et al..Decreased KAI-1 expression in advanced renal cell carcinoma[J].Chinese Journal of Cancer,2000,19(6). |
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| Authors: | KONG Xian-guo ZHANG Yuan-fang DING Qiang |
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| Abstract: | Objective: To investigate the expression of KAI-1 mRNA in renal cell carcinoma and the relationship with the metastasis. Method: RT-PCR was used to detect KAI-1 mRNA expression in specimens from 35 cases with renal cancer and adjacent normal kidney tissues. Results: KAI-1 expression rate in renal cancer was significantly lower than that in normal kidney tissues (P< 0.05); tumors of patients with extrarenal invasion or regional lymph node metastasis (stage Ⅲ orⅣ ) had significantly lower KAI-1 expression levels than tumors of patients with stage Ⅰ or Ⅱ disease (P< 0.05).Conclusion: Decreased expression of the KAI-1 gene may be related to disease progression in patients with renal cancer. |
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| Keywords: | Kidney neoplasms KAI-1 Metastasis |
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