新生儿溶血性黄疸患者过氧化状况的初步探讨

测定20例新生儿G6PD缺陷性溶血及13例新生儿ABO溶血病的红细胞SOD活性及血浆MDA浓度变化，结果显示：（1）SOD明显低于对照组，MDA明显高于对照组：（2）光疗前、后MDA变化无显著性差异，而光疗后SOD升高；（3）MDA与血清微量胆红素浓度呈正相关（r为0.412，P＜0.01）。以上结果提示：（1）新生儿溶血性黄疸患者遭受的过氧化损害增强：（2）光疗并不加重对溶血性黄疸新生儿的过氧化损害：（3）MDA变化可作为新生儿溶血程度的检测指标之一。

Preliminary study on the peroxidative status of the neonatal hemolytic jaundice

The changes of the erythrocyte superxide dismutase (SOD) activities and the plasmas malondiadehyde (MDA) concentrations were measured in 20 cases of hemolytic neonates with G6PD deficiency in erythyocytes, and were done in 13 cases of the ABO incompatibility neonates. The result showed: (1) SOD was significantly lower and the MDA was significantly higher in the both of the two groups than those in the control. (2) MDA was no significant difference between postphototherapy and prephototherapy, but SOD was elevated in postphototherapy than that in prephototherapy. (3) MDA was positively related to the serum bilirumbin concentration. (r=0. 412, P<0. 01). These results suggested: (1) there was a enhancing lipid peroxidative damage to the neonatal hemolytic jaundice. (2) phototherapy would nol enhance the lipid peroxidative damage to the hemolytic neonates. (3) lhe changes of MDA might be as a reliable guide to the neonatal hemolysis.