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Impact of Antiretroviral Therapy on Health-Related Quality of Life among South African Women in the CAPRISA 002 Acute Infection Study |
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| Authors: | Andrew Tomita Nigel Garrett Lise Werner Jonathan K. Burns Nelisiwe Ngcobo Nomthandazo Zuma Koleka Mlisana Francois van Loggerenberg Salim S. Abdool Karim |
| Affiliation: | 1. Centre for the AIDS Programme of Research in South Africa (CAPRISA), Doris Duke Medical Research Institute, University of KwaZulu-Natal, Private Bag X7, Congella, 4013, South Africa 2. Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa 3. Columbia University Mailman School of Public Health, New York, NY, USA 4. Medical Microbiology Department, National Health Laboratory Service, Durban, South Africa 5. The Global Health Network, Centre for Tropical Medicine, University of Oxford, Oxford, UK |
| Abstract: | Concerns are often raised regarding potentially adverse effects of antiretroviral therapy (ART) on health-related quality of life (HRQoL), but there is limited longitudinal data to prove this. Building on our prior investigation, we examined the impact of ART on HRQoL among HIV-infected South African women with extensive follow-up in the CAPRISA 002 Acute Infection Cohort Study. Overall HRQoL and five sub-domains [physical well-being (PWB), emotional well-being (EWB), functional and global well-being (FGWB), social well-being (SWB) and cognitive functioning (CF)] were assessed using the Functional Assessment of HIV Infection (FAHI) instrument. Our analyses comparing FAHI scores between pre-ART (established infection) and ART phases using paired Wilcoxon signed-rank tests and adjusted mixed-effects regression models revealed improvements on ART in overall HRQoL, and in PWB, EWB, and SWB, but not in FGWB and CF. No long-term adverse impact of ART on HRQoL was detected, providing additional non-biomedical support to early treatment strategies. |
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