原发性震颤患者的认知功能及抑郁情绪的研究

目的探讨原发性震颤(essential tremor,ET)患者的认知功能和情绪障碍及其相互关系。方法采用简易智能量表(MMSE)、汉语失语症检查法口语表达分测验及阅读分测验、Rey复杂图形测验、修订韦氏成人智力量表中的数字广度分测验、相似性分测验、符号-数字分测验、威斯康星卡片分类测验、连线测验、词语流畅性测验和画钟测验,对40例ET患者和40名年龄、文化程度、利手等相匹配的健康对照进行认知评定。同时,采用汉密尔顿抑郁量表(HAMD)测评患者的抑郁情绪,HAMD评分8分为伴有抑郁症状。结果ET组的Rey复杂图形测验(t=6.66,P0.001)、数字广度分测验(顺)(t=3.32,P0.001)、符号-数字分测验(t=4.18,P0.001)、威斯康星卡片分类测验各项(P0.05)、连线测验(t=3.59,P0.001)、词语流畅性测验(t=-3.98,P0.001)和画钟测验(t=-4.18,P0.001)等各项成绩均较正常对照组低;而在汉语失语症检查法口语表达分测验及阅读分测验、相似性测验中两组间得分差异无统计学意义(P0.05);患者组各项认知测验成绩与震颤强度和病程无关(P0.05);52.5%(21/40)ET患者合并抑郁症状,但多为轻度抑郁(71.4%);抑郁症状的发生与年龄有关(2=27.03,P0.001),多出现在50岁以下的患者(85.7%);是否伴有抑郁的ET组之间各项认知测验得分差异无统计学意义(P0.05)。结论ET患者存在多认知域的功能障碍,尤以执行功能、注意力及记忆受损较为明显;ET患者中抑郁症状的发生率较高。

Cognitive function and emotional disorder in patients with essential tremor

Objective To investigate the cognitive function and emotional disorder and their interrelationships in patients with essential tremor(ET). Methods The cognitive function was evaluated by using scales such as mini-mental state examination (MMSE), aphasia buttery of Chinese for oral-test and read-test, Rey-Osterreith complex figure (ROF), digit span (DS), similarties tests, symbols-digital test, Wisconsin card sorting test, trail making test A, verbal fluency test and clock drawing test in fourty cases and fo...