Effects of cannabidiol in animal models predictive of antipsychotic activity |
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Authors: | A W Zuardi J Antunes Rodrigues J M Cunha |
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Institution: | (1) School of Medicine of Ribeirão Preto, USP, 14049 Ribeirão Preto, SP, Brazil;(2) School of Medicine, UF, 38400 Uberlandia, MG, Brazil |
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Abstract: | The effects of cannabidiol (CBD) were compared to those produced by haloperidol in rats submitted to experimental models predictive of antipsychotic activity. Several doses of CBD (15–480 mg/kg) and haloperidol (0.062–1.0 mg/kg) were tested in each model. First, CBD increased the effective doses 50% (or) ED50 of apomorphine for induction of the sniffing and biting stereotyped behaviors. In addition, both CBD and haloperidol reduced the occurrence of stereotyped biting induced by apomorphine (6.4 mg/kg), increased plasma prolactin levels and produced palpebral ptosis, as compared to control solutions. However, CBD did not induce catalepsy even at the highest doses, in contrast to haloperidol. Such a pharmacological profile is compatible with that of an atypical antipsychotic agent, though the mechanism of action is uncertain and may not be identical to that of the dopamine antagonists. |
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Keywords: | Cannabidiol Cannabinoids Antipsychotic drugs Antipsychotic screening Stereotyped behavior Prolactin Catalepsy Palpebral ptosis |
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