Effects of hormones on phospholipase A2 activity in rat skin |
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| Authors: | P V Sergeev T V Ukhina N L Shimanovskii |
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| Institution: | (1) Department of Molecular Pharmacology and Radiobiology, Medico-Biological Faculty, Russian State Medical University, Moscow |
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| Abstract: | We studied the effects of hydrocortisone, progesterone, estradiol, and testosterone on phospholipase A2 activity in plasma and lysosomal membranes of rat dermis and epidermis. The dermal enzyme was more sensitive to estradiol,
while epidermal to testosterone. The effects of progesterone and hydrocortisone were mediated by lipocortin-like protein,
while estradiol and testosterone directly by modulated phospholipase A2 activity
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 1, pp. 70–72, January, 2000 |
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| Keywords: | skin dermis epidermis estradiol hydrocortisone progesterone testosterone phospholipase A 2 |
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