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Unbiased stereological quantification of unmyelinated fibers in the rat brain white matter |
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| Authors: | Chen Li Shu Yang Wei Zhang Xiaoyan Shi Weiwei Wang Jens R Nyengaard Yong Tang |
| Institution: | 1. Department of Neurology, First Affiliated Hospital, Chongqing Medical University, Chongqing, PR China;2. Institute for Basic Medical Sciences, Chongqing Medical University, Chongqing, PR China;3. Department of Histology and Embryology, Chongqing Medical University, Chongqing, PR China;4. Stereology and Electron Microscopy Research Laboratory and MIND Center, Aarhus University, Aarhus, Denmark |
| Abstract: | We applied unbiased stereological principles to estimate the volume of white matter and the total volume and length of the unmyelinated fibers in the white matter of the rat brain. The mean volume of the rat brain white matter was 119 mm3. The mean total length and the mean total volume of the unmyelinated fibers in the white matter were 323 km and 35 mm3, respectively. The described method provides a useful tool for future quantitative studies of changes in the unmyelinated fibers of white matter in various experimental conditions and in various neurodegenerative diseases. |
| Keywords: | Length Volume Unmyelinated fibers White matter Rat Stereology |
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