Investigation of 3111T/C polymorphism of the CLOCK gene in obese individuals with or without binge eating disorder: Association with higher body mass index |
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Authors: | Palmiero Monteleone Alfonso Tortorella Ludovico Docimo Mauro N. Maldonato Benedetta Canestrelli Luca De Luca Mario Maj |
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Affiliation: | 1. Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy;2. XI Divisione di Chirurgia Generale e dell’Obesità, University of Naples SUN, Naples, Italy;3. University of Basilicata, Potenza, Italy |
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Abstract: | Loss of circadian patterning of metabolism-related functions seems to play a role in the pathogenesis of obesity; therefore, it is reasonable to hypothesize that the functional 3111T/C single nucleotide polymorphism (SNP) of the (Circadian locomotor output cycles kaput) CLOCK gene may have a part in the genetic susceptibility to obesity. The aim of this study was to assess the frequencies of 3111T/C CLOCK gene SNP in overweight/obese subjects with or without binge eating disorder (BED) as compared to normal weight healthy controls. A total of 284 Caucasian subjects, including 92 normal weight healthy subjects and 192 overweight/obese patients (107 with BED) participated into the study. Genotype and allele frequencies did not significantly differ between normal weight controls and overweight/obese patients with and/or without BED. However, overweight/obese patients carrying the CC genotype had significantly higher values of body mass index (BMI) as compared to those carrying the CT and/or TT genotypes. Moreover, obese class III individuals had a significantly higher frequency of both the CC genotype and the C allele as compared to individuals with BMI < 40 kg/m2. Present findings show for the first time that the 3111T/C SNP of the CLOCK gene is not associated to human obesity and/or BED, but it seems to predispose obese individuals to a higher BMI. |
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Keywords: | CLOCK gene Obesity Binge eating disorder |
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