Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis,and inhibits the proliferation of human gastric cancer cells in vitro |
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| Authors: | Wei-Hao Sun Feng Zhu Guo-Sheng Chen Han Su Cheng Luo Qin-Shi Zhao Yuan Zhang Yun Shao Jian Sun Su-Ming Zhou Guo-Xian Ding Yun-Lin Cheng |
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| Affiliation: | 1. Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu, PR China;2. Department of Gastroenterology, Shanghai First People’s Hospital, Shanghai Jiaotong University, Shanghai 200080, PR China;3. Department of Medicine, Government Office Hospital of Jiangsu Provincial People’s Government, Nanjing 210024, Jiangsu, PR China;4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, PR China;5. Institute of Biomedicine, University of Turku, Turku Fin-20520, Finland;6. Department of Chemistry, University of Hong Kong, Hong Kong, PR China |
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| Abstract: | Gastrin and cyclooxygenase-2 (COX-2) play important roles in the carcinogenesis and progression of gastric cancer. However, it remains unknown whether the combination of cholecystokinin-2 (CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer. Here, we demonstrated that the combination of AG-041R (a CCK-2 receptor antagonist) plus NS-398 (a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition, apoptosis induction, down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells. These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone. |
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| Keywords: | Cholecystokinin-2 receptor Cyclooxygenase-2 MKN-45 cell Proliferation Apoptosis |
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