Enhancement of adipogenesis induction by conditioned media obtained from cancer cells |
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| Authors: | Takeshi Hirano Haruki Morii Koji Nakazawa Daisuke Murakami Akihisa Yamashita Junpei Asahi Hiroshi Orimo Kazuyoshi Tamae Yoshiki Tokura |
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| Affiliation: | 1. Graduate School of Environmental Engineering, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka 808-0135, Japan;2. Department of Chemical Processes and Environments, Faculty of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka 808-0135, Japan;3. Department of Dermatology, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka 807-8555, Japan;4. Division of Teacher Training, Faculty of Education and Culture, University of Miyazaki, Miyazaki 889-2192, Japan |
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| Abstract: | White adipose tissue is a multifunctional endocrine organ that synthesizes and secretes cytokine-like proteins termed adipokines. In the present study, the effects of cancer-derived medium on adipogenesis were examined. We prepared conditioned media from cancer cell lines, and cultured preadipocytes in the conditioned media. After 10 days of culture, intracellular lipid droplet accumulation was measured. We observed that the conditioned media significantly induced adipogenesis or enhanced the adipogenesis induced by adipogenesis inducers. Although we could not define the factors, these undefined factors derived from cancer cells may induce adipogenesis, and the resulting adipogenesis may affect cancer development. |
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| Keywords: | Adipogenesis Cancer Cell-to-cell interactions Conditioned medium Intracellular lipid droplet |
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