DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients |
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Authors: | Chi-Un Pae Antonio Drago Jung-Jin Kim Ashwin A Patkar Tae-Youn Jun Chul Lee Laura Mandelli Diana De Ronchi In-Ho Paik Alessandro Serretti |
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Institution: | 1. Department of Psychiatry, Kangnam St. Mary''s Hospital, The Catholic University of Korea College of Medicine, South Korea;2. Department of Psychiatry and Behavioural Sciences, Duke University, South Korea;3. Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy |
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Abstract: | Dysbindin gene (DTNBP1) has been associated with schizophrenia, but literature findings are inconsistent, and further analyses are required. This study is aimed to investigate if a set of DTNBP1 variations might influence clinic psychotic phenotype or treatment response in a sample of 240 Korean schizophrenic in-patients. Four variants have been selected (rs3213207; rs1011313; rs16876759; rs2619522) on the basis of previous findings of association with schizophrenia, bipolar disorder and antidepressant response. Single marker analysis gave marginal results. Haplotype analysis identified a significant association between A–A (rs3213207(A/G), rs1011313(A/G)) haplotype and lower PANSS total and positive scores at baseline (p = 0.01; 0.02) and at discharge (p = 0.008; 0.005). Covariate analysis revealed a more stable significant association between A–A haplotype and baseline scores. These results suggest a protective effect of A–A haplotype on psychotic positive symptoms at baseline. |
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Keywords: | Dysbindin Schizophrenia Gene Association |
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