Apicidin down-regulates human papillomavirus type 16 E6 and E7 transcripts and proteins in SiHa cervical cancer cells |
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| Authors: | Michał W. Łuczak Paweł P. Jagodzinski |
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| Affiliation: | Poznań University of Medical Sciences, Department of Biochemistry and Molecular Biology, 6 Swiecickiego Street, 60-781 Poznań, Poland |
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| Abstract: | Virtually all cervical cancer morbidities are associated with genital skin or mucosa cell infection with human papillomavirus (HPV). The HPV oncogenic proteins E6 and E7 are able to inactivate p53 and Rb proteins, which results in malignant transformation. |
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| Keywords: | Apicidin Signaling molecules Histone deacetylase Cervical cancer cells |
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