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| 橄榄解酒饮对急性酒精性肝损伤大鼠细胞凋亡及Bcl-2蛋白表达的影响 | |
| 引用本文： | 朱平生,王宇亮,彭成,刘琦.橄榄解酒饮对急性酒精性肝损伤大鼠细胞凋亡及Bcl-2蛋白表达的影响[J].上海中医药杂志,2006,40(5):58-59. |
| 作者姓名： | 朱平生 王宇亮 彭成 刘琦 |
| 作者单位： | 1. 上海中医药大学肝病研究所,上海,201203;河南中医学院肝病研究所,河南,郑州,450008 2. 河南中医学院肝病研究所,河南,郑州,450008 3. 北京中医药大学,北京,100029 |
| 基金项目： | 河南省国际合作项目(0346660002) |
| 摘 要： | 目的观察橄榄解酒饮对大鼠急性酒精性肝损伤的干预效果,探讨其对肝细胞凋亡进程的调节作用。方法采用白酒灌胃造模法,每天连续两次灌胃白酒,每次间隔1h,连续5d后取肝组织切片,检测凋亡细胞指数和Bcl-2蛋白,并与护肝胶囊对照。结果橄榄解酒饮可显著降低凋亡指数、增加Bcl-2蛋白阳性表达,与对照组比较差异有统计学意义(P<0.05)。结论橄榄解酒饮通过抑制肝细胞凋亡而减轻肝组织损伤。 |
| 关 键 词： | 橄榄解酒饮 急性酒精性肝损伤 细胞凋亡 大鼠 动物实验 |
| 文章编号： | 1007-1334（2006）05-0058-02 |
| 收稿时间： | 2006-01-16 |
| 修稿时间： | 2006年1月16日 |
Effects of "Ganlan Jiejiu Beverage" on Apoptosis Index and Expressions of Bcl-2 in Rats Model of Acute Alcoholic Hepatic Injury |
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| ZHU Ping-sheng,WANG Yu-liang,PENG Cheng,LIU Qi.Effects of "Ganlan Jiejiu Beverage" on Apoptosis Index and Expressions of Bcl-2 in Rats Model of Acute Alcoholic Hepatic Injury[J].Shanghai Journal of Traditional Chinese Medicine,2006,40(5):58-59. | |
| Authors: | ZHU Ping-sheng WANG Yu-liang PENG Cheng LIU Qi |
| Institution: | 1. Shanghai University of Traditional Chinese Medicine; 2. Henan College of Traditional Chinese Medicine; 3. Beijing University of Traditional Chinese Medicine |
| Abstract: | Objective To observe the preventive and therapeutic effects of "Ganlan Jiejiu Beverage" on acute hepatic injury in the rat and to study preliminary effects on apoptosis index and expressions of Bcl-2.Methods The acute alcoholic hepatic injury model was made by stomach perfusion of spirits for 5 days, and hepatic homogenate on the 5th day was determined, and the results were compared with those of Hugan Capsules. Results "Ganlan Jiejiu Beverage" could significantly decrease apoptosis index and expressions of Bcl-2 compared with the control group. Conclusion "Ganlan Jiejiu Beverage" has good drunk-preventing, alcoholism-relieving and liver-protecting actions. |
| Keywords: | "Ganlan Jiejiu Beverage" acute alcoholic hepatic injury apoptosis rat |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |