T2* mapping of ovine intervertebral discs: Normative data for cervical and lumbar spine |
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| Authors: | Anna‐Katharina Kolf Tobias Hesper Christoph Schleich Harish S. Hosalkar Silvia Jankowiak Claudio Cacchi Gerald Antoch Christoph Zilkens Rüdiger Krauspe Bernd Bittersohl |
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| Affiliation: | 1. Department of Orthopedics, Medical Faculty, University Düsseldorf, Düsseldorf, Germany;2. Department of Diagnostic and Interventional Radiology, Medical Faculty, University Düsseldorf, Düsseldorf, Germany;3. Center for Hip Preservation and Children's Orthopedics, San Diego, California;4. Hosalkar Institute for Joint Preservation and Injury Care, San Diego, California;5. Department of Pathology, Medical Faculty, University Düsseldorf, Düsseldorf, Germany |
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| Abstract: | To obtain T2* values in histologically evaluated healthy ovine intervertebral discs of the cervical and lumbar spine. Intervertebral discs of nine sheep and nine lambs underwent histological assessment with the modified Boos score for grading of disc degeneration. Discs with a score <10 points (maximum = 40 points) underwent T2* mapping (n = 64). Mid‐sagittal T2* values were obtained in five regions: Anterior annulus fibrosus, anterior nucleus pulposus, central nucleus pulposus, posterior nucleus pulposus, and posterior annulus fibrosus. We noted a zonal T2* distribution with high values in the central nucleus and low T2* values in the anterior and posterior annulus fibrosus. The T2* values were higher in lamb than in sheep IVDs for both cervical and lumbar spine (p < 0.001). The T2* values were also higher in the cervical than in the lumbar spine (p = 0.029 for sheep and p < 0.001 for lamb IVDs). The T2* values obtained in these ovine intervertebral discs can serve as baseline values for future T2* measurements both in health and disease. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:717–724, 2016. |
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| Keywords: | T2* mapping MRI intervertebral disc ovine histology |
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