聚己酸内酯及其在医药领域的应用

目前，对聚己酸内酯的性质和应用的研究日益增多。本文综述了聚己酸内酯材料的制备、一般理化性质、降解吸收性质和在临床及给药系统中的应用等。聚己酸内酯一般由开环聚合得到，为半结晶性聚合物，有较好的柔韧性。该材料降解属于水解反应，不在体内积蓄，排泄完全；可以作为手术缝线、骨折固定材料、药物载体等使用。由于它安全、低毒、可生物降解，所以在医药领域得到广泛应用。

Studies on a Kind of New Biodegradable Material--Polycaprolactone and Developments in Medical Area

Nowdays, there are more and more researches on characters and applications of polycaprolactone(PCL). This paper reviews the researches of polycaprolactone, including its synthesis, physical and chemical properties, biodegradation, absorption properties, and its applications in clinical use and drug delivery systems. PCL can be from open ring polymerizaion. It is a kind of semi crystalline polymer, and has good flexbiligy. The degradation reaction of PCL is hydrolysis. PCL is not cumulated in the body, and can be totally excreted. It can be used as suture, material for fixation of bone fracture, vector of drug, etc . PCL is widely used in medical area because of its safety, low toxicity, bidegradability.