| HLA-DRB1＊14和＊15等位基因与肝癌的相关性 |
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| 引用本文： | 黄爱春,吴继周,吴健林,陈务卿,韦颖华,罗双艳,宁秋悦,李兰兰. HLA-DRB1＊14和＊15等位基因与肝癌的相关性[J]. 临床肝胆病杂志, 2010, 26(4): 420-422 |
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| 作者姓名： | 黄爱春 吴继周 吴健林 陈务卿 韦颖华 罗双艳 宁秋悦 李兰兰 |
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| 作者单位： | 广西医科大学第一附属医院感染性疾病科,南宁,530021 |
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| 基金项目： | 国家自然科学基金，广西壮族自治区卫生厅课题 |
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| 摘 要： | 目的探讨HLA-DRB1＊14和＊15等位基因与肝癌发生的相关性。方法以40例原发性肝癌患者作为病例组,以135例健康人作为对照组,应用PCR-SSP方法对研究对象外周血的HLA-DRB1等位基因进行检测,分析其表达与原发性肝癌的相关性。结果 HLA-DRB1＊14在病例组中的分布频率较对照组显著增高（χ2=9.925,P=0.002,OR=3.450,95%CI：1.555～7.655）,HLA-DRB1＊15在病例组和对照组中的分布频率的差异无统计学意义（χ2=1.260,P=0.262,OR=1.538,95%CI：0.723～3.274）。结论 HLA-DRB1＊14可能是原发性肝癌的易感基因,HLA-DRB1＊15可能与原发性肝癌的发生无明显关系。
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| 关 键 词： | 等位基因 肝肿瘤 HLA-DR抗原 |
The correlation between HLA-DRB1*14 and HLA-DRB1*15 alleles and hepatocellular carcinoma |
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| Affiliation: | HUANG Ai-chun,WU Ji-zhou,WU Jian-lin,et al.(The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China) |
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| Abstract: | Objective To study the relationship between HLA-DRB1＊14 and HLA-DRB1＊15 genes and hepatocellular carcinoma.Methods 40 patients with hepatocellular carcinoma and 135 healthy controls were included in the study.HLA-DRB1 genes were detected by PCR-SSP.Results The frequency of HLA-DRB1＊14 was significantly higher than the control group（χ2=9.925,P=0.002,OR=3.450,95%CI：1.555～7.655）,however,no significant difference was found in HLA-DRB1＊15 frequency between the two groups（χ2=1.260,P=0.262,OR=1.538,95%CI：0.723～3.274）.Conclusion HLA-DRB1＊14 might be the responsible gene for the development of hepatocellular carcinoma with a minor effect by HLA-DRB1＊15 genes. |
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| Keywords: | alleles liver neoplasms HLA-DR antigens |
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