电焊作业工人血清SOD、GSH-Px和MDA改变及其影响因素

目的：探讨电焊作业对工人体内的脂质过氧化水平的影响。方法：对125名电焊工和50名对照人员进行了问卷和血清SOD，GSH－Px和MDA的测定。结果：手工电弧焊组和CO2保护焊组的SOD，GSH－Px显著低于对照组，MDA显著高于对照组；3项指标在各接触剂量组间差异无显著性，也不存在剂量－效应关系；回归分析显示3项指标与累积接触剂量无关。结论：电焊作业可引起电焊工体内氧化负荷加重，但这种作用不存在明显的蓄积现象，也未发现剂量－效应关系。

Changes in serum levels of superoxide dismutase,glutathione peroxidase and malondialdehyde and their influencing factors in electric welders

Objective To study the effects of exposure to electric welding on the level of lipid peroxidations in welders.Methods Totally,125 electric welders and 50 controls were interviewed with questionnaire and their serum levels of total superoxide dismutase (T SOD),glutathione peroxidase(GSH Px)and malondialdehyde(MDA)were determined.Results Serum levels of T SOD and GSH Px were significantly lower in the electric welders and those protected with carbon dioxide than those in the controls,and their level of MDA was significantly higher than that in the controls.There was no significant difference in the three above mentioned indices between the groups with varied exposures to electric welding,and there was no dose effect relationship between them.Regression analysis showed no relationship between the three indices and cumulative exposure dose.Conclusion Exposure to electric welding could increase their oxidation load in the welders,but no obviously cumulative phenomenon of such an effect and no dose effect relationship were found.