丙肝康对大鼠肝损伤及免疫功能的影响

用牛血清白蛋白复制大鼠肝纤维化 ,静脉注射 3次后 ,给予丙肝康治疗。在不同阶段分别测定下述指标 :腹腔巨噬细胞对葡萄球菌的吞噬功能、Fc及 C3b受体活性、CIC、血 T淋巴细胞计数、脾脏形态、AL T、MAO、肝胶原蛋白及肝组织的病理观察。结果 :肝损伤程度持续加重 ,最终形成肝硬化。在此过程中 ,动物的单核巨噬细胞的吞噬功能持续降低 ,血 T淋巴细胞含量降低 ,脾瘀血肿大 ,白髓及脾小体萎缩 ,CIC增高。丙肝康对上述病变有明显的抑制作用。提示 :IC沉积是牛血清白蛋白所致肝损伤的主要因素 ,在此过程中 ,免疫功能下降阻碍了对 IC的清除 ,加重了肝损伤。丙肝康通过提高机体的免疫功能减轻肝损伤

IMMUNOLOGIC EFFECTS OF BINGGANKANG ORAL LIQUID ON RATS WITH INJURED LIVER

Objective:To investegate the immunity effects of Binggankang (BGK) oral liquid on experimental liver fibrosis and function of immune response in rats.Methods:The livers of rats were injured by bovine serum albumen from vein.After three times,BGK was orally administrated to some injured rats.These indexes needed to be observed:body weight,TP,ALB,phagocytic index to staphylococcus,Fc,C 3b receptor numbers in macrophage,ALT,AST,circulatory immune complex(CIC),MAO,hydroxproline in liver,liver morphoachitecture,splenic morphcachitecture,percent of T lymphocytes in rats serum.Results:The levels of phagocytic index to staphylococcus,Fc,C 3b receptor numbers,ALB,percent of T lymphocytes in BGK group were higher than those in the model group (P<0.05,P<0.01).These levels of ALT,MAO,CIC,hydroxproline in liver were lower than those in the model group (P<0.05,P<0.01).Conclusion:BGK could obviously reduce the degree of hepatofibrosis in rats and congestion and hydrops in spleen,increase immune function in injured rats,eliminated CIC and protect effectively the injured liver of rats. [