C-reactive protein in childhood meningitides |
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Authors: | Harish Kumar Pemde Kamlesh Harish Y P Thawrani S Shrivastava K M Belapurkar |
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Institution: | (1) Department of Pathology and Professor, Department, J.A. Group of Hospitals and Gajra Raja Medical College, Gwalior;(2) A-312, Kidwai Nagar (East), 110 023 New Delhi |
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Abstract: | Utility of C-reactive protein (CRP) latex agglutination test in meningitis was evaluated. Serum CRP test was positive in 100%
cases of meningitic groups and 53% cases of “no meaningitis (NM)” group. Cerebrospinal fluid (CSF) CRP test was positive in
100% cases of pyogenic meningitis, whereas it was negative in 95% cases of tuberculous meningitis and 100% cases of NM group.
CSF CRP test showed 100% sensitivity and negativbe predictive values, 95–100% specificity and 94–100% positive predictive
values for various inter-group differentiations. This study conclluded that CSF CRP positive cases should be considered as
pyogenic meningitis unless proved otherwise. Routine use of this simple, reliable and inexpensive test is recommended for
rapid diagnosis and differential diagnosis f meningitis. |
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Keywords: | C-reactive protein Cerebrospinal fluid Meningitis |
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