无创呼吸机治疗COPD合并慢性呼吸衰竭的疗效观察

目的探讨无创呼吸机联合药物治疗在治疗慢性阻塞性肺疾病合并慢性呼吸衰竭方面的疗效。方法选择2010年6月～2011年6月于我院呼吸内科就诊的152例慢性阻塞性肺疾病合并慢性呼吸衰竭患者，随机分为对照组和观察组，每组76例，对照组给予常规药物治疗，观察组给予常规药物治疗并加用无创正压通气治疗。观察并记录两组在治疗前后的心率（HR）、呼吸频率（RR）、血氧饱和度（SaO2）、动脉血pH、氧分压（PaO2）、二氧化碳分压（PaCO2）。结果治疗后，两组分别进行组内比较，HR、RR、PaCO2均明显降低，PaO2、SaO2均显著升高，具有统计学意义（P〈0．05）。观察组各项指标的改善幅度均较对照组显著（P〈0．05）。结论采用无创通气技术治疗慢性阻塞性肺疾病合并慢性呼吸衰竭患者，有利于纠正机体的酸中毒及电解质紊乱，缓解病情，缩短住院天数，降低死亡率，具有一定的临床意义。

Clinical Study of Noninvasive Positive Pressure Ventilation in Respiratory Failure of Chronic Obstructive Pulmonary Disease

Objective To discuss the effect of noninvasive mechanical in the treatment of the ventilator patients with chronic obstructive pulmonary disease combined with chronic respiratory failure. Methods To choose from June 2010 to June 2011 in our respiratory medicine clinic of 152 cases of chronic obstructive pulmonary disease combined with chronic respiratory failure patients,then divided them into observation group and control group randomly,each group of 76. Control group to conventional treatments,the observation group to conventional treatments and add with noninvasive positive pressure ventilation treatment. Attention and record two groups＇ HR,RR,pH,PaO2,PaCO2,SpO2. Results After treatment,the two groups were compared in the group,HR,RR,PaCO2 were reduced significantly,and PaOz,SaO2 were significantly increased,a statistically significant （P〈0.05）. The observation group of patients with each index of amplitude than control group improved significantly （P〈0.05）. Conclusion Noninvasive ventilation technology can alleviate the illness,shorten days in hospital,reduce mortality,and has a certain clinical significance.