| Rho激酶与支架内再狭窄 |
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| 引用本文： | 王建红综述,李敬诚审校.Rho激酶与支架内再狭窄[J].中国动脉硬化杂志,2010,18(6):502-504. |
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| 作者姓名： | 王建红综述 李敬诚审校 |
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| 作者单位： | 中国人民解放军第三军医大学附属大坪医院神经内科,重庆市,410010 |
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| 摘 要： | 目的 支架内再狭窄与血管平滑肌分化、迁移,细胞外基质的过度增值所致新生内膜增生密切相关.Rho激酶参与支架置入引起的新生内膜增生的调节.长期抑制Rho激酶的表达可阻止新生内膜的增生,可能成为防止支架内再狭窄的一种方法.
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| 关 键 词： | Rho激酶 支架 支架内再狭窄 |
| 收稿时间： | 2009/12/19 0:00:00 |
| 修稿时间： | 2010/4/13 0:00:00 |
Rho-kinase and In-stent Restenosis |
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| WANG Jian-Hong,and LI Jing-Cheng.Rho-kinase and In-stent Restenosis[J].Chinese Journal of Arteriosclerosis,2010,18(6):502-504. |
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| Authors: | WANG Jian-Hong and LI Jing-Cheng |
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| Institution: | Department of Neurology,Daping Hospital,Third Military Medical University,Chongqing 400042,China |
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| Abstract: | ISR is essentially due to vascular smooth muscle cell (VSMC) proliferation and migration,and excessive extracellular matrix production,leading to neointima formation. Rho-kinase,a major regulator of VSMC proliferation and migration,after stenting plays its role in the neointimal formation.Long-term inhibition of Rho-kinase suppresses in-stent neointimal formation by multiple mechanisms. Inhibition of the Rho/Rho kinase pathway should provide a useful strategy to prevent ISR. |
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| Keywords: | Rho-kinase Stent In-stent Restenosis |
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