剖宫产术预防性使用抗菌药物的临床研究

目的探讨不同的抗菌药物使用方式在剖宫产术中预防感染的临床效果。方法将120例择期剖宫产孕妇随机分为2组:研究组60例,术前30 min静脉滴注头孢呋辛1.5 g、甲硝唑0.5 g,术后相同剂量2次/d,连用1～2 d;对照组60例,术前不用药,术后同样药物、相同剂量和方法连用3～5 d。结果两组术后发病率、发热发生率、术后感染发生率、术后白细胞升高差异均无统计学意义(P>0.05);但术后住院天数和抗菌药物费用研究组明显低于对照组(P<0.05)。结论围手术期应用抗菌药物是预防剖宫产术后感染的有效方法,术前30 min给药,短程应用更加合理。

Study of preventative prophylactic antibiotic drugs on postoperative infectious in cesarean section

Objective To research the clinical effects of different antibiotic administration models on prevention of postoperative infectious in cesarean section.Methods 120 selective cesarean section pregnant women were randomly divided into two groups.60 cases in study group received cefuroxime sodium(1.5 g)+ metronidazole(0.5 g)at the time of induction of anesthesia,and the same measure was used for 1～2 d at postoperative time.60 cases in control group who do not use antibiotics preoperatively,received the same dosage of the two drugs for 3～5 d at postoperative time.Results There were no significant differences between the two groups in rates of postoperative sick,fever,infection and increase of white blood cell.The postoperative hospital days and the antibiotics expense of study group were significantly lower than those of control group(P<0.05).Conclusion Prophylactic antibiotics play a significant role in preventing postoperative infection in cesarean section.It is more reasonable to have antibiotic administration 30 min before operation and use short-course models.