膀胱癌患者术后不同剂量卡介苗腔内灌注所产生的免疫效果及副作用比较

目的比较膀胱癌患者术后不同剂量卡介苗腔内灌注所产生的免疫效果及副作用。方法将入选病例随机分为2组,术后分别灌注卡介苗60、120mg,用流式细胞仪检测灌注前、后外周血T细胞亚群的变化,作为评价免疫效果的指标;同时比较2组的副作用发生情况。结果与灌注前比较,灌注后CD4因子2组均明显升高(P<0.05),灌注后CD8因子2组均明显降低(P<0.05);灌注后2组间比较,无显著性差异(P>0.05)。60mg组副作用发生率及程度明显低于120mg组。结论小剂量卡介苗灌注可取得与大剂量相近的免疫效果,副作用低。

Immunization & Side Effect Comparison of BCG Intracavitary Perfusion at Different Dose for Patients with Bladder Carcinoma After Surgery

OBJECTIVE:To compare the immune effect and side effect of BCG intracavitary instillation at different dose for patients with bladder carcinoma after the surgery.METHODS:The patients were divided into two groups randomly and treated with BCG intracavitary instillation after surgery.The dose was 60mg and 120mg,respectively.The peripheral blood T lymphocyte subsets were tested as the index of immune effect evaluation with flow cytometry before and after instillation.The side effects of the two groups were also compared.RESULTS:The level of CD4 factor statistically increased after instillation in both groups(P<0.05);CD8 obviously decreased(P<0.05).There was no statistical difference between two groups(P>0.05);the incidence and degree of side effects was obviously lower in group of 60mg than in group of 120mg.CONCLUSION:The similar immune effects and lower side effects were obtained with low dose BCG intracavitary instillation compared with the large dose.